Sequences of COVID-19 in a child with WAGR syndrome: A case report

Sami Jomaa; Dana Shubat; Mamdoh AlTabban; Ibrahim Abdullah; Sawsan Ismail; Lina Khouri

doi:10.1016/j.amsu.2021.102732

Sequences of COVID-19 in a child with WAGR syndrome: A case report

Ann Med Surg (Lond). 2021 Sep:69:102732. doi: 10.1016/j.amsu.2021.102732. Epub 2021 Aug 17.

Authors

Sami Jomaa¹, Dana Shubat¹, Mamdoh AlTabban¹, Ibrahim Abdullah^{2

3}, Sawsan Ismail⁴, Lina Khouri^{1

5}

Affiliations

¹ Faculty of Medicine, Damascus University, Damascus, Syria.
² Bachelor of Pharmacy, Damascus University, Damascus, Syria.
³ Genetics and Bioinformatics Association, Syria.
⁴ Department of Pathology, Faculty of Medicine, Tishreen University, Lattakia, Syria.
⁵ Program Director of Children University Hospital, Damascus University, Children University Hospital, Damascus, Syria.

Abstract

Introduction: and importance: WAGR syndrome is a rare genetic disorder consist of Wilms tumor, Aniridia, Genitourinary abnormalities, and Intellectual disability. During the enduring COVID-19 pandemic, it has become extremely important to document the properties of SARS-CoV-2 and its interactions with other diseases. Herein, we present the first case of Syrian child with WAGR syndrome that has been affected by COVID-19.

Case presentation: a 17-month-old boy was diagnosed with WAGR syndrome. During the follow-up, he developed rhinorrhea, cough, and moderate dyspnea with no fever. Computed tomography scan was normal and polymerase chain reaction test was positive. The child started an oxygen therapy with broad-spectrum antibiotics based on laboratory findings. His vital signs and laboratory values improved gradually without any further complications.

Discussion: COVID-19 has a special interest regarding its course in children. Although the clinical presentation varies, the current data reveal a better prognosis in children.

Conclusion: SARS-CoV-2 infection may result in non-specific symptoms and normal CT scan findings in children with WAGR syndrome. The accurate diagnosis, effective isolation and monitoring of the child, and successful management can improve the prognosis and shorten the infection period.

Keywords: 2019-nCoV disease; COVID-19; Case report; Children; WAGR syndrome.

Publication types

Case Reports