Transforming growth factor-beta inhibits endothelial cell proliferation

Biochem Biophys Res Commun. 1986 May 29;137(1):295-302. doi: 10.1016/0006-291x(86)91209-x.


Transforming growth factor-beta (TGF-beta) is an inhibitor of the proliferation of bovine aortic endothelial cells in culture. Basal cell growth in serum-containing medium and cell proliferation stimulated by fibroblast growth factor (FGF) are inhibited by TGF-beta in a dose-dependent manner. Half-maximal inhibition occurs at an inhibitor concentration of 0.5-1.0 ng/ml. TGF-beta does not appear to be cytotoxic and cells treated with the inhibitor grow normally after removal of TGF-beta. High concentrations of FGF are ineffective in overcoming TGF-beta-induced inhibition of cell proliferation, suggesting that antagonism of growth factor-induced cell proliferation by TGF-beta is of a noncompetitive nature.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cattle
  • Cell Cycle / drug effects
  • Endothelium / cytology*
  • Endothelium / drug effects
  • Fibroblast Growth Factors / antagonists & inhibitors
  • In Vitro Techniques
  • Peptides / pharmacology*
  • Transforming Growth Factors


  • Peptides
  • Fibroblast Growth Factors
  • Transforming Growth Factors