Factor XII deficiency and von Willebrand's disease in a family of miniature poodle dogs

Cornell Vet. 1986 Jan;76(1):3-10.


The simultaneous occurrence of factor XII deficiency and von Willebrand's disease (VWD) is described in a family of Miniature Poodles affected concurrently with a familial non-spherocytic hemolytic anemia. Although there was a dominant distribution of factor XII deficiency in this family of dogs, only the dogs suffering from non-spherocytic hemolytic anemia had concurrent VWD gene expression. Neither the factor XII deficient dogs nor the VWD carrier dogs displayed bleeding tendencies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Blood Coagulation Factors / analysis
  • Dog Diseases / diagnosis*
  • Dog Diseases / genetics
  • Dogs
  • Factor XII Deficiency / diagnosis
  • Factor XII Deficiency / genetics
  • Factor XII Deficiency / veterinary*
  • Female
  • Male
  • von Willebrand Diseases / diagnosis
  • von Willebrand Diseases / genetics
  • von Willebrand Diseases / veterinary*


  • Blood Coagulation Factors