Cerebroside of the dimorphic human pathogen, Candida albicans

Chem Phys Lipids. 1987 Jan-Feb;43(1):1-12. doi: 10.1016/0009-3084(87)90012-0.


Structural studies on the cerebroside isolated from the yeast form of a dimorphic pathogen, Candida albicans were carried out using fast atom bombardment mass spectrometry (FAB/MS), proton magnetic resonance spectrometry, gas chromatography-mass spectrometry and usual chemical methods. The component sugar was only glucose attached to ceramide in a beta-configuration. The major fatty acid was 2-hydroxystearic acid (62%). The predominant long chain base was identified as 9-methyl-C18-sphinga-4,8-dienine which is widely distributed in fungi and reported to be essential to the fruit-inducing activity of fungi. Therefore, the structure of the main molecular species of the cerebroside was determined to be N-2-hydroxystearoyl-1-O-beta-glucosyl-9-methyl-C18-sphinga-4 ,8-dienine. Cerebroside prepared from the mycelial form of C. albicans has the same structure.

MeSH terms

  • Candida albicans / analysis*
  • Cerebrosides / analysis*
  • Gas Chromatography-Mass Spectrometry / methods
  • Humans
  • Magnetic Resonance Spectroscopy / methods
  • Mass Spectrometry / methods


  • Cerebrosides