Role of vitamin A in prevention and treatment of sarcoma 180 in mice

Chemotherapy. 1987;33(3):211-8. doi: 10.1159/000238497.


The effect of deficiency of vitamin A and its supplementation on growth of murine sarcoma 180 was evaluated. The efficacy of cyclophosphamide under depleted and supplemented condition of the vitamin was also scrutinized. Supplemental vitamin A helped to check progression of tumour growth and also increased the effectiveness of chemotherapy. The action is possibly mediated through the host immune system.

MeSH terms

  • Animals
  • Ascites / drug therapy
  • Body Weight / drug effects
  • Cyclophosphamide / therapeutic use
  • Lymphocyte Activation / drug effects
  • Male
  • Mice
  • Sarcoma 180 / drug therapy*
  • Vitamin A / metabolism
  • Vitamin A / therapeutic use*
  • Vitamin A Deficiency / physiopathology


  • Vitamin A
  • Cyclophosphamide