Abstract
Retrovirus-mediated gene transfer was used to mark cell lineages in vivo in the postnatal rat retina. Labelled clones contained up to three different cell types: three types of neurons or two types of neurons and a Müller glial cell. This indicates that a single retinal progenitor can generate remarkably diverse cell types near the end of development.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Aging
-
Animals
-
Cell Transformation, Viral
-
Genes, Viral
-
Neuroglia / cytology
-
Neuroglia / physiology*
-
Rats
-
Retina / cytology
-
Retina / growth & development*
-
Retina / physiology*
-
Retinal Ganglion Cells / cytology
-
Retinal Ganglion Cells / physiology*
-
Retroviridae / genetics