A common progenitor for neurons and glia persists in rat retina late in development

Nature. 1987 Jul;328(6126):131-6. doi: 10.1038/328131a0.


Retrovirus-mediated gene transfer was used to mark cell lineages in vivo in the postnatal rat retina. Labelled clones contained up to three different cell types: three types of neurons or two types of neurons and a Müller glial cell. This indicates that a single retinal progenitor can generate remarkably diverse cell types near the end of development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aging
  • Animals
  • Cell Transformation, Viral
  • Genes, Viral
  • Neuroglia / cytology
  • Neuroglia / physiology*
  • Rats
  • Retina / cytology
  • Retina / growth & development*
  • Retina / physiology*
  • Retinal Ganglion Cells / cytology
  • Retinal Ganglion Cells / physiology*
  • Retroviridae / genetics