Polymorphism of plasminogen in healthy individuals and patients with cerebral infarction

Hum Hered. 1986;36(3):137-42. doi: 10.1159/000153617.

Abstract

Phenotyping of plasma plasminogen (PLG) was carried out by the method of agarose gel isoelectric focusing followed by immunofixation or immunoblotting. The allele frequencies calculated from healthy Japanese individuals (n = 795) were as follows: PLG*1 = 0.9440, PLG*2 = 0.0189, PLG*A = 0.0076, PLG*A2 = 0.0006, PLG*B = 0.0138, PLG*B2 = 0.0013, and PLG*C = 0.0138. The PLG phenotype distribution in a group of patients with cerebral infarction (n = 125) was also studied. The allele frequencies were PLG*1 = 0.960, PLG*2 = 0.016, PLG*A = 0.012, and PLG*B = 0.012. No statistically significant association was found between PLG types and cerebral infarction.

Publication types

  • Comparative Study

MeSH terms

  • Alleles
  • Cerebral Infarction / blood*
  • Cerebral Infarction / genetics
  • Gene Frequency
  • Humans
  • Phenotype
  • Plasminogen / genetics*
  • Polymorphism, Genetic*
  • Reference Values

Substances

  • Plasminogen