Elimination of nadolol by patients with renal impairment

Br J Clin Pharmacol. 1979;7 Suppl 2(Suppl 2):227S-231S. doi: 10.1111/j.1365-2125.1979.tb04694.x.


1 Nadolol excretion was studied in 24 patients with chronic renal failure. 2 The amount of nadolol excreted during the 120-h period after receiving the drug ranged from less than 1% in functionally anephric, patients up to 11.5% in patients with average creatinine clearance of 57.9 +/- 3.6 ml/min/1.73 m2. 3 Renal clearance of nadolol was found to correlate with creatinine clearance; nadolol elimination is retarded in patients with renal failure. 4 Nadolol serum half-life is prolonged in proportion to the remaining renal function. Therefore, dosage intervals in renal patients receiving nadolol should be adjusted to creatinine clearance. 5 Haemodialysis effectively reduced serum concentration of the drug; it may therefore be a useful therapy for drug intoxication.

MeSH terms

  • Adolescent
  • Adrenergic beta-Antagonists / blood
  • Adrenergic beta-Antagonists / metabolism*
  • Adrenergic beta-Antagonists / urine
  • Adult
  • Aged
  • Creatinine / metabolism
  • Female
  • Humans
  • Kidney Failure, Chronic / physiopathology*
  • Kinetics
  • Male
  • Middle Aged
  • Propanolamines / blood
  • Propanolamines / metabolism*
  • Propanolamines / urine
  • Renal Dialysis


  • Adrenergic beta-Antagonists
  • Propanolamines
  • Creatinine