Effect of alpha-methyldopa excreted in human milk on the breast-fed infant

Helv Paediatr Acta. 1985 Apr;40(1):83-6.


A nursing infant whose mother took alpha-methyldopa (alpha-MD) was followed for 3 months. Analysis of maternal serum and milk as well as the infant's serum and urine for alpha-MD revealed that the drug was excreted into maternal milk, absorbed by the infant and excreted in her urine, but no adverse clinical effects were noted during the follow-up period. alpha-MD is excreted in human milk in concentrations that probably do not harm the breast-fed infant.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Breast Feeding*
  • Female
  • Humans
  • Hypertension / blood*
  • Hypertension / drug therapy
  • Infant, Newborn
  • Kinetics
  • Methyldopa / blood*
  • Methyldopa / therapeutic use
  • Milk, Human / metabolism*
  • Pregnancy
  • Puerperal Disorders / blood*
  • Puerperal Disorders / drug therapy


  • Methyldopa