Secondary Sjögren's syndrome and chromosome six markers

Tissue Antigens. 1985 May;25(5):247-54. doi: 10.1111/j.1399-0039.1985.tb00447.x.

Abstract

Patients with Sjögren's syndrome (SS) in association with either Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE) or Sclerodactyly were tested for HLA-A, B and Dr antigens and the phenotypes of the 4th component of complement (CA). Significant associations were identified between HLA-Bw62, Dr4, C4B2.9, C4A8 and females with SS-RA. The MHC antigen frequencies noted for secondary Sjögren's syndrome differed from those reported for their respective primary diseases and the implications of these observations are discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Arthritis, Rheumatoid / complications
  • Chromosomes, Human, 6-12 and X*
  • Female
  • Genetic Markers
  • HLA Antigens / genetics*
  • HLA-A Antigens
  • HLA-B Antigens
  • HLA-DR Antigens
  • Histocompatibility Antigens Class II / genetics
  • Humans
  • Lupus Erythematosus, Systemic / complications
  • Male
  • Middle Aged
  • Multiple Sclerosis / complications
  • Sjogren's Syndrome / complications
  • Sjogren's Syndrome / genetics*
  • Sjogren's Syndrome / immunology

Substances

  • Genetic Markers
  • HLA Antigens
  • HLA-A Antigens
  • HLA-B Antigens
  • HLA-DR Antigens
  • Histocompatibility Antigens Class II