A novel dual near-infrared fluorescent probe for bioimaging and visualization of viscosity in acute alcoholic liver injury

Ruonan Wang; Xucong Zhou; Bingxue Li; Ru Ding; Jingqian Han; Ying Wang; Aixia Meng; Jin Zhou

doi:10.1039/d4cc01222d

A novel dual near-infrared fluorescent probe for bioimaging and visualization of viscosity in acute alcoholic liver injury

Chem Commun (Camb). 2024 May 7. doi: 10.1039/d4cc01222d. Online ahead of print.

Authors

Ruonan Wang¹, Xucong Zhou¹, Bingxue Li¹, Ru Ding¹, Jingqian Han¹, Ying Wang^{2

3}, Aixia Meng¹, Jin Zhou¹

Affiliations

¹ School of Pharmacy, School of Nursing, School of Basic Medical Sciences, Shandong Second Medical University, Weifang 261053, China. zhoujin@sdsmu.edu.cn.
² Faculty of Education, Qufu Normal University, Qufu 273165, China.
³ School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao 266071, China. wangying@uor.edu.cn.

PMID: 38712712
DOI: 10.1039/d4cc01222d

Abstract

A dual NIR fluorescent probe Cy-ND is developed for viscosity sensing with λ_ex/em = 766/806 nm, making it apt for biological analysis, whose response is validated through DFT and TDDFT computations. Cy-ND successfully detected viscosity changes amidst acute alcohol-induced liver injury and liver ischemia-reperfusion injury.