Prevention of osteoradionecrosis: a randomized prospective clinical trial of hyperbaric oxygen versus penicillin

J Am Dent Assoc. 1985 Jul;111(1):49-54. doi: 10.14219/jada.archive.1985.0074.


A prospective randomized trial comparing hyperbaric oxygen and systemic antibiotics in the prevention of osteoradionecrosis was presented. The results indicated, in a high-risk population who required tooth removal in irradiated mandibles, that up-front hyperbaric oxygen produced an incidence of osteoradionecrosis of 5.4% as compared with the antibiotic group of 29.9% (P = .005). Hyperbaric oxygen should be considered a prophylactic measure when post-irradiation dental care involving trauma to tissue is necessary.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Clinical Trials as Topic
  • Humans
  • Hyperbaric Oxygenation*
  • Mandible / radiation effects
  • Mandibular Diseases / prevention & control*
  • Osteoradionecrosis / prevention & control*
  • Penicillin G / therapeutic use*
  • Prospective Studies
  • Radiation Injuries / prevention & control*
  • Random Allocation
  • Risk
  • Time Factors
  • Tooth Extraction / adverse effects
  • Wound Healing


  • Penicillin G