The bronchodilator effect and pharmacokinetics of theobromine in young patients with asthma

J Allergy Clin Immunol. 1985 Nov;76(5):703-7. doi: 10.1016/0091-6749(85)90674-8.


The bronchodilator effect of a 10 mg/kg dose of theobromine (3,7-dimethylxanthine) was compared with that of 5 mg/kg of theophylline (1,3-dimethylxanthine) in young patients with asthma. Bronchodilation, as assessed by forced vital capacity, forced expiratory volume in the first second, forced expiratory flows at 25%, 50%, and 75% of vital capacity, and percent of forced expiratory volume in the first second/forced vital capacity did not differ significantly between the two drugs. After each drug bronchodilation peaked at 2 hours and lasted for 6 hours, although it was not always statistically significant for theobromine. The mean peak serum concentrations of both drugs, the time at which peak serum concentrations occurred, and elimination half-life values were similar for theobromine and theophylline.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Asthma / drug therapy*
  • Child
  • Female
  • Forced Expiratory Volume
  • Humans
  • Kinetics
  • Male
  • Theobromine / metabolism
  • Theobromine / therapeutic use*
  • Theophylline / therapeutic use
  • Time Factors


  • Theophylline
  • Theobromine