Maprotiline (Ludiomil) in depression: a report of a monitored release study in general practice

J Int Med Res. 1977:5 Suppl 4:112-5.


In a three-week study of 10,000 general practice patients with depressive illness, a once nightly dose of maprotiline 75 mg (Ludiomil) was effective therapy in three-quarters of the patients who completed the study. At this dose the drug was well tolerated, and troublesome side-effects presented in only a small percentage of patients. Drowsiness was the most commonly reported side-effect, and the main reason for stopping treatment. The drug was acceptable to most physicians, and in this study was used in a wide age range of patients and over a broad spectrum of depressive illness.

MeSH terms

  • Adult
  • Aged
  • Anthracenes / therapeutic use*
  • Depression / drug therapy*
  • Female
  • Humans
  • Male
  • Maprotiline / administration & dosage
  • Maprotiline / adverse effects
  • Maprotiline / therapeutic use*
  • Middle Aged


  • Anthracenes
  • Maprotiline