Thorotrast-associated cholangiocarcinoma: an epidemiologic and clinicopathologic study

Cancer. 1982 Oct 1;50(7):1408-15. doi: 10.1002/1097-0142(19821001)50:7<1408::aid-cncr2820500728>;2-t.


Six cases of Thorotrast-associated cholangiocarcinoma (TACC) are studied and compared with eight previously reported cases as well as with cases of non-TACC. TACC shares some epidemiologic features both with non-TACC as well as Thorotrast-associated angiosarcoma (TAAS) but appears to occur in younger patients than non-TACC. There is an apparent increased prevalence of both benign and malignant thyroid disease in the current group of patients with TACC; previous epidemiologic studies have not identified this phenomenon. Thorotrast-associated hepatic fibrosis was present in all 14 TACC cases; otherwise, both non-TACC and TACC are clinically and morphologically similar. Bile duct dysplasia and/or transition to adenocarcinoma, which occurred in all the AFIP cases, are seldom described in case reports of either TACC or non-TACC; in the current study they served to validate the intrahepatic origin of the tumors.

Publication types

  • Comparative Study

MeSH terms

  • Adenoma, Bile Duct / chemically induced*
  • Adenoma, Bile Duct / complications
  • Adenoma, Bile Duct / pathology
  • Adult
  • Aged
  • Bile Duct Neoplasms / chemically induced*
  • Bile Duct Neoplasms / complications
  • Bile Duct Neoplasms / pathology
  • Bile Ducts / pathology
  • Epidemiologic Methods
  • Female
  • Humans
  • Liver / pathology
  • Male
  • Microscopy, Electron, Scanning
  • Middle Aged
  • Thorium Dioxide / adverse effects*
  • Thorium Dioxide / analysis
  • Thyroid Diseases / complications
  • Time Factors


  • Thorium Dioxide