The elimination of sulbactam alone and combined with ampicillin in patients with renal dysfunction

J Antimicrob Chemother. 1983 Jun;11(6):583-7. doi: 10.1093/jac/11.6.583.


Sulbactam, a beta-lactamase inhibitor, was given as a single agent to 12 subjects with varying degrees of renal dysfunction. The half-life in normal subjects was 1.1 h and increased to 21.3 h in those with terminal renal failure. Sulbactam together with ampicillin was given to a further five subjects. It was concluded that if the two agents are given together, the plasma ratio of one to the other will remain constant whatever the renal function.

MeSH terms

  • Ampicillin / administration & dosage*
  • Drug Combinations
  • Half-Life
  • Humans
  • Kidney Diseases / metabolism*
  • Penicillanic Acid / administration & dosage
  • Penicillanic Acid / metabolism*
  • Sulbactam


  • Drug Combinations
  • Ampicillin
  • Penicillanic Acid
  • Sulbactam