Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein

Biochem Biophys Res Commun. 1984 May 16;120(3):885-90. doi: 10.1016/s0006-291x(84)80190-4.


A purified protein derived from the twisted beta-pleated sheet fibrils in cerebrovascular amyloidosis associated with Alzheimer's disease has been isolated by Sephadex G-100 column chromatography with 5 M guanidine-HC1 in 1 N acetic acid and by high performance liquid chromatography. Amino acid sequence analysis and a computer search reveals this protein to have no homology with any protein sequenced thus far. This protein may be derived from a unique serum precursor which may provide a diagnostic test for Alzheimer's disease and a means to understand its pathogenesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / metabolism*
  • Amino Acids / analysis
  • Amyloid / isolation & purification*
  • Amyloid beta-Peptides
  • Amyloidosis / metabolism
  • Brain / blood supply*
  • Chemical Phenomena
  • Chemistry
  • Chromatography, High Pressure Liquid
  • Humans


  • Amino Acids
  • Amyloid
  • Amyloid beta-Peptides