The regulation of physiological changes during mammalian aging

Q Rev Biol. 1976 Mar;51(1):49-83. doi: 10.1086/409053.


Much evidence suggests that intrinsic molecular or cellular aging mechanisms need not be invoked to explain most age-related cellular changes and pathologcical conditions. Analysis of a widely scattered literature indicates that hormones and neural factors regulate a great number of cellular aging phenomena of mammals. It is proposed that age-related changes after maturation result from an extension of the neural and endocrine mechanisms that control earlier development and that produce a regulatory cascade of changing neural, endocrine, and target-tissue interactions.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Aging*
  • Animals
  • Brain / physiology
  • Disease
  • Endocrine Glands / physiology
  • Female
  • Genotype
  • Humans
  • Longevity
  • Male
  • Movement Disorders / physiopathology
  • Neurotransmitter Agents / physiology
  • Ovary / physiology
  • Pigments, Biological / metabolism
  • Pituitary Gland / physiology
  • Reproduction


  • Neurotransmitter Agents
  • Pigments, Biological