COPD and endobronchial polyposis associated with hypogammaglobulinemia. Are proteolytic enzymes involved?

Chest. 1982 Jul;82(1):127-9. doi: 10.1378/chest.82.1.127.


The present report describes a patient who had severe obstructive lung disease in association with acquired hypogammaglobulinemia. Evidence obtained by bronchoalveolar lavage is presented that suggests that his lung disease resulted from both a marked increase in elastase load and a reduction in protease inhibitor function.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Agammaglobulinemia / complications*
  • Bronchoscopy
  • Humans
  • Lung / analysis
  • Lung Diseases, Obstructive / diagnostic imaging
  • Lung Diseases, Obstructive / etiology*
  • Lung Diseases, Obstructive / immunology
  • Male
  • Polyps / etiology
  • Radiography
  • Therapeutic Irrigation
  • Trachea / pathology