Quantitative relationship between HBeAg and DNA polymerase activity in sera from patients with chronic active hepatitis during a three-month period

J Med Virol. 1980;5(4):295-302. doi: 10.1002/1096-9071(1980)5:4<295::aid-jmv1890050405>3.0.co;2-5.


In eight patients with biopsy-confirmed chronic active hepatitis (CAH), hepatitis B e antigen (HBeAg) levels and DNA polymerase (DNA-P) activity were assayed three times a week for six weeks and once a week for another six weeks. HBeAg levels were rather constant, whereas DNA-P activity fluctuated. No correlation was observed between the quantities of HBeAg and DNA-P activity. An unexpected fluctuation in DNA-P activity was noted in all patients after an influenza vaccination.

MeSH terms

  • Chronic Disease
  • DNA-Directed DNA Polymerase / blood*
  • Hepatitis B / enzymology
  • Hepatitis B / immunology*
  • Hepatitis B Antigens / analysis*
  • Hepatitis B Surface Antigens / analysis
  • Hepatitis B e Antigens / analysis*
  • Humans
  • Influenza A virus / immunology
  • Influenza Vaccines / immunology
  • Radioimmunoassay
  • Vaccination


  • Hepatitis B Antigens
  • Hepatitis B Surface Antigens
  • Hepatitis B e Antigens
  • Influenza Vaccines
  • DNA-Directed DNA Polymerase