Histological changes in the thyroid gland induced by monosodium glutamate in mice

Acta Anat (Basel). 1981;109(2):97-102. doi: 10.1159/000145371.


The effect of monosodium glutamate (MSG) on the thyroid gland of mice is studied. MSG induces marked histological changes in the thyroid tissue, indicative of hypothyroidism. The follicular epithelium, is greatly compressed and the follicles have enlarged due to distension with the accumulation of colloid. The histological picture of the thyroid gland remains unchanged for the animals sacrificed after short-term (13 weeks) and long-term (52 weeks) treatment. MSG, therefore, has a cumulative effect. The hypothyroidism is attributed to the influence of the drug on hypothalamus-pituitary function and the secretion of hormones responsible for the thyroid metabolism.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Colloids
  • Epithelium / pathology
  • Female
  • Glutamates / adverse effects*
  • Hypothyroidism / chemically induced
  • Hypothyroidism / pathology
  • Mice
  • Sodium Glutamate / administration & dosage
  • Sodium Glutamate / adverse effects*
  • Thyroid Gland / drug effects*
  • Thyroid Gland / pathology


  • Colloids
  • Glutamates
  • Sodium Glutamate