Cefazolin in children with renal insufficiency

J Pediatr. 1980 Feb;96(2):335-9. doi: 10.1016/s0022-3476(80)80842-0.


Cefazolin (7 mg/kg) were administered to 11 children with renal insufficiency and to ten children on hemodialysis. The serum half-life of the drug was progressively prolonged as glomerular filtration rate fell. The serum half-life of cefazolin was variably prolonged in those children on hemodialysis, but their serum levels of cefaxolin had dropped by 35 to 65% during dialysis. Most had no measurable level prior to the next dialysis. Dosage recommendations are made for both groups of patients.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Biological Assay
  • Cefazolin / administration & dosage
  • Cefazolin / blood*
  • Cefazolin / urine
  • Child
  • Child, Preschool
  • Creatinine / blood
  • Creatinine / urine
  • Half-Life
  • Humans
  • Kidney Failure, Chronic / blood*
  • Kidney Failure, Chronic / therapy
  • Renal Dialysis
  • Time Factors


  • Creatinine
  • Cefazolin