Abstract
Using a standardized laboratory rat model of burn wound sepsis, a regimen of once a day application of Silvadene has been found to be more effective treatment than Sulfamylon or cerium-Silvadene. Delaying treatment following infection resulted in decreased survival. Possible reasons for difference in mortality are once-daily application, or perhaps a change in sensitivity between drugs and the infective organism (Ps. aeruginosa) over time.
MeSH terms
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Administration, Topical
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Animals
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Burns / drug therapy*
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Burns / mortality
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Cerium / administration & dosage
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Cerium / therapeutic use
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Disease Models, Animal
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Mafenide / therapeutic use
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Pseudomonas Infections / drug therapy
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Pseudomonas Infections / mortality
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Rats
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Silver Sulfadiazine / administration & dosage
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Silver Sulfadiazine / therapeutic use*
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Sulfadiazine / therapeutic use*
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Time Factors
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Wound Infection / drug therapy*
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Wound Infection / mortality
Substances
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Sulfadiazine
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Cerium
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Mafenide
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Silver Sulfadiazine