Gene transfer into human hemopoietic progenitor cells

Br Med Bull. 1995 Jan;51(1):167-91. doi: 10.1093/oxfordjournals.bmb.a072945.


Considerable progress is being made in the transfer of genetic material to hematopoietic stem cells. In this chapter we describe how gene transfer is being used to: mark marrow and peripheral blood progenitor cells prior to autologous transplantation, to track their fate on reinfusion and to detect contaminating tumorigenic cells; modulate immunocyte function--important in immunologic disorders and perhaps in cancer therapy; generate tumor vaccines from tumor cells isolated from marrow; correct single gene defects--the 'classical' concept of gene therapy; and finally to modify the drug sensitivity of progenitor cells--enabling them to resist the suppressive effects of cytotoxic drugs during cancer therapy and perhaps providing a mechanism for in vivo selection of gene modified cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Drug Resistance / genetics
  • Gene Transfer Techniques*
  • Genetic Therapy / methods*
  • Globins / genetics
  • Hematopoietic Stem Cells*
  • Humans
  • Neoplasms / therapy
  • Transplantation, Autologous
  • Virus Diseases / therapy


  • Globins