Polymorphism of the gene encoding a human minimal potassium ion channel (minK)

Gene. 1994 Dec 30;151(1-2):339-40. doi: 10.1016/0378-1119(94)90685-8.

Abstract

A gene (minK) that encodes a minimal potassium channel has been cloned recently. We describe in this paper a human minK sequence which differs from the original sequence with a single A-->G at position 112. This resulted in a change from a Ser codon (AGT) to a Gly codon (GGT) and created a new MspAI restriction site. Of the 32 alleles from 16 subjects studied, 25 had this newly discovered sequence and 7 had the previously described sequence.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Animals
  • Base Sequence
  • Chromosomes, Human, Pair 11
  • Codon / genetics
  • DNA Primers
  • Genetic Carrier Screening
  • Genetic Linkage
  • Glycine
  • Hominidae / genetics*
  • Humans
  • Long QT Syndrome / genetics*
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*
  • Potassium Channels / genetics*
  • Potassium Channels, Voltage-Gated*
  • Serine

Substances

  • Codon
  • DNA Primers
  • Potassium Channels
  • Potassium Channels, Voltage-Gated
  • potassium channel protein I(sk)
  • Serine
  • Glycine

Associated data

  • GENBANK/L33815