[Inhibition of elastin hydrolysis, catalyzed by human leukocyte elastase and cathepsin G, by the Bowman-Birk type soy inhibitor]

Biokhimiia. 1994 Nov;59(11):1739-45.
[Article in Russian]


Cathepsin G stimulates the hydrolysis of elastin from bovine neck ligament catalyzed by human leukocyte elastase. Stimulation factor depends on the ratio of the enzyme concentrations and ionic strength and equals 1.0-2.0. The classical Bowman-Birk inhibitor from soya retards strongly the hydrolysis of elastin catalyzed by leukocyte elastase, cathepsin G and the mixture of both. The inhibitory effect is practically unaffected by the adsorption of the enzymes on elastin, prolongation of the enzymatic reaction and ionic strength.

Publication types

  • English Abstract

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Catalysis
  • Cathepsin G
  • Cathepsins / metabolism*
  • Cattle
  • Elastin / antagonists & inhibitors*
  • Humans
  • Hydrolysis
  • Leukocyte Elastase / metabolism*
  • Leukocytes / enzymology*
  • Molecular Sequence Data
  • Osmolar Concentration
  • Pancreatic Elastase / metabolism*
  • Serine Endopeptidases
  • Trypsin Inhibitor, Bowman-Birk Soybean / pharmacology*


  • Trypsin Inhibitor, Bowman-Birk Soybean
  • Elastin
  • Cathepsins
  • Serine Endopeptidases
  • CTSG protein, human
  • Cathepsin G
  • Pancreatic Elastase
  • Leukocyte Elastase