Omeprazole reduces preoperative gastric fluid acidity and volume in children

Can J Anaesth. 1994 Oct;41(10):925-9. doi: 10.1007/BF03010936.


To explore the effects of oral omeprazole on preoperative gastric fluid pH and volume in children, 104 healthy in-patients aged 4-9 yr were randomly allocated to four groups (n = 26). Subjects in the Omeprazole-Omeprazole Group received two doses of omeprazole (20 mg per dose), those in the Placebo-Placebo Group, two doses of placebo, those in the Placebo-Omeprazole and Omeprazole-Placebo Groups, one dose each of the two preparations by mouth. For each treatment regimen, the first medication was administered at 9:00 p.m. on the night before surgery and the second at 5:30 a.m. on the morning of the day of surgery (three hours preoperatively). Children undergoing elective surgery were offered 10 of apple juice three hours before induction of anaesthesia. After induction of anaesthesia and tracheal intubation, gastric fluid was aspirated through a large-bore, multiorifice orogastric tube and analyzed for pH and total fluid volume. The administration of omeprazole at bedtime before surgery increased gastric pH (3.3 +/- 1.3 vs 2.0 +/- 0.6, P < 0.05) in comparison with placebo, as did two doses of omeprazole (pH = 4.8 +/- 1.6, P < 0.05). A single dose of omeprazole administration on the morning of the day of surgery failed to increase gastric pH. There was a reduction in the number of children with a pH < 2.5 and a volume > 0.4 in the Omeprazole-Omeprazole and Omeprazole-Placebo Groups, compared with the Placebo-Placebo or Placebo-Omeprazole Groups.(ABSTRACT TRUNCATED AT 250 WORDS)

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Anesthesia, Inhalation
  • Beverages
  • Child
  • Child, Preschool
  • Elective Surgical Procedures
  • Fruit
  • Gastric Acid / metabolism*
  • Gastric Acidity Determination
  • Gastric Juice / drug effects*
  • Gastric Juice / metabolism*
  • Humans
  • Hydrogen-Ion Concentration
  • Intubation, Gastrointestinal
  • Intubation, Intratracheal
  • Omeprazole / administration & dosage
  • Omeprazole / therapeutic use*
  • Placebos
  • Premedication*
  • Prospective Studies


  • Placebos
  • Omeprazole