As part of a larger, retrospective investigation of homeless women's wholistic family planning needs, we examined spiritual/religious practices in relationship to mental health status and substance use. Ninety-two percent of our sample reported one or more spiritual/religious practices, such as praying, attending worship services, or reading religious materials. Forty-eight percent of the women reported the use of prayer as significantly related to less use of alcohol and/or street drugs, fewer perceived worries, and fewer depressive symptoms.