A yeast artificial chromosome contig on mouse chromosome 11 encompassing the nu locus

Eur J Immunol. 1994 Jul;24(7):1721-3. doi: 10.1002/eji.1830240742.


Mutations at the nude locus disrupt the homing process of T cell progenitor cells to the thymic rudiment, a key aspect of T cell differentiation. Here, we map the nude locus to a set of overlapping yeast artificial chromosomes (YAC) clones covering a genetic interval of about 0.5 centi Morgan on mouse chromosome 11. These results provide a suitable starting point to molecularly clone the nude gene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Chromosome Mapping / veterinary*
  • Chromosomes, Artificial, Yeast
  • Crosses, Genetic
  • Genetic Markers
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C3H
  • Mice, Inbred C57BL
  • Mice, Nude / genetics*
  • Molecular Sequence Data


  • Genetic Markers