Post-radiation gliomas

Tumori. 1994 Jun 30;80(3):220-3. doi: 10.1177/030089169408000311.


Aims and background: Radiotherapy is important in the treatment of neoplasm of the central nervous system, but various side effects, particularly neoplastic, have been described. Recently, post-radiation gliomas have been reported.

Methods: The authors review 88 cases of cerebral glioma following radiotherapy in patients operated for neoplasms of the nervous system, including 6 personal cases of post-radiation gliomas treated in the Neurosurgical Division of the Department of Neurological Sciences, "La Sapienza" University, Rome. The criteria used to define this unusual pathologic association are discussed.

Results: There was a male predominance. Post-radiation gliomas were particularly malignant, the average dose was 33 Gy, and average free latency was 9.6 years. The first disease was most frequently acute lymphatic leukemia.

Conclusions: Post-radiation gliomas have particular features but do not present a histologic or clinical behavior different from analogous spontaneous gliomas. The fact that 88 cases have been reported in recent years suggests that a thorough biological, clinical studies be carried out on this association.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Brain Neoplasms / etiology*
  • Female
  • Glioma / etiology*
  • Humans
  • Male
  • Neoplasms, Radiation-Induced / etiology*
  • Radiotherapy / adverse effects*