Vibroacoustic stimulation in fetal sheep: effect on cerebral glucose utilization and behavioral state

J Dev Physiol. 1993 Apr;19(4):171-7.

Abstract

Behavioral state and cerebral glucose utilization were measured in six fetal sheep subjected to high intrauterine sound pressures created with a vibroacoustic stimulator pressed against the maternal abdomen. The signal consisted of a complex waveform that varied over time with a 50% duty cycle. An implanted hydrophone showed highest spectral levels between 3,000-16,000 Hz. The pulsed sound resulted in a significant loss of fetal rapid eye movement and non-rapid eye movement sleep. The stimulus also resulted in a disruption in the normally close relationship between these sleep states and cerebral glucose utilization rates in the brain as a whole and in its component parts.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acoustic Stimulation*
  • Animals
  • Autoradiography
  • Brain / embryology*
  • Brain / metabolism
  • Female
  • Fetus / physiology*
  • Glucose / metabolism*
  • Pregnancy
  • Sheep
  • Sleep*

Substances

  • Glucose