The role of TH1 and TH2 cells in a rodent malaria infection

Science. 1993 Jun 25;260(5116):1931-4. doi: 10.1126/science.8100366.


CD4+ T cells play a major role in protective immunity against the blood stage of malaria, but the mechanism of protection is unclear. By adoptive transfer of cloned T cell lines, direct evidence is provided that both TH1 and TH2 subsets of CD4+ T cells can protect mice against Plasmodium chabaudi chabaudi infection. TH1 cells protect by a nitric oxide-dependent mechanism, whereas TH2 cells protect by the enhancement and accelerated production of specific immunoglobulin G1 antibody.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Protozoan / biosynthesis
  • Arginine / analogs & derivatives
  • Arginine / pharmacology
  • CD4-Positive T-Lymphocytes / immunology*
  • Cell Line
  • Female
  • Immunoglobulin G / biosynthesis*
  • Lymphocyte Depletion
  • Malaria / immunology*
  • Mice
  • Mice, Inbred Strains
  • Nitrates / blood
  • Nitric Oxide / metabolism*
  • Plasmodium chabaudi / immunology*
  • T-Lymphocyte Subsets / immunology*
  • omega-N-Methylarginine


  • Antibodies, Protozoan
  • Immunoglobulin G
  • Nitrates
  • omega-N-Methylarginine
  • Nitric Oxide
  • Arginine