Effects of two high-fat diets with different fatty acid compositions on glucose and lipid metabolism in healthy young women

Am J Clin Nutr. 1994 Jun;59(6):1310-6. doi: 10.1093/ajcn/59.6.1310.


Effects of two experimental diets with a relatively high fat content--one enriched with saturated fatty acids (SAFA-diet) and the other with a low content of erucic acid rapeseed oil and rich in monounsaturated fatty acids (MUFA-diet)--on glucose and lipid metabolism were examined in healthy young women. The study was carried out with a randomized, crossover study design with each diet lasting 3 wk and a 2-wk washout period between the experimental diets. Glucose area under the curve during the intravenous glucose tolerance test (glucose dose 300 mg/kg, plasma samples before glucose dose and at 10-min intervals for 90 min) was significantly lower and the glucose disappearance rate after a glucose injection tended to be steeper after the MUFA-diet than after the SAFA-diet. After the MUFA-diet serum total cholesterol was 21.6% lower and serum low-density-lipoprotein cholesterol 29.5% lower than after the SAFA-diet, but high-density-lipoprotein cholesterol did not differ between the diets. The results give suggestive evidence that the dietary fatty acid composition affects glucose tolerance of healthy subjects.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Dietary Fats / administration & dosage
  • Dietary Fats / metabolism*
  • Fatty Acids / administration & dosage
  • Fatty Acids / metabolism*
  • Fatty Acids, Monounsaturated / administration & dosage
  • Fatty Acids, Monounsaturated / metabolism*
  • Female
  • Glucose / metabolism*
  • Glucose Tolerance Test
  • Humans
  • Lipid Metabolism*


  • Dietary Fats
  • Fatty Acids
  • Fatty Acids, Monounsaturated
  • Glucose