Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components

Science. 1994 Jan 7;263(5143):92-5. doi: 10.1126/science.8272873.

Abstract

A recently defined family of cytokines, consisting of ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), and interleukin-6 (IL-6), utilize the Jak-Tyk family of cytoplasmic tyrosine kinases. The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. Activation of these kinases occurs as a result of ligand-induced dimerization of the receptor beta components. Unlike other cytokine receptors studied to date, the receptors for the CNTF cytokine family utilize all known members of the Jak-Tyk family, but induce distinct patterns of Jak-Tyk phosphorylation in different cell lines.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antigens, CD*
  • Cell Line
  • Ciliary Neurotrophic Factor
  • Cytokine Receptor gp130
  • Cytokines / metabolism
  • Cytokines / pharmacology*
  • Enzyme Activation
  • Growth Inhibitors*
  • Interleukin-6*
  • Janus Kinase 1
  • Janus Kinase 2
  • Leukemia Inhibitory Factor
  • Lymphokines*
  • Membrane Glycoproteins / metabolism*
  • Nerve Tissue Proteins / metabolism
  • Nerve Tissue Proteins / pharmacology
  • Oncostatin M
  • Peptides / metabolism
  • Peptides / pharmacology
  • Phosphorylation
  • Protein-Tyrosine Kinases / metabolism*
  • Proteins / metabolism
  • Proto-Oncogene Proteins*
  • Receptor, Ciliary Neurotrophic Factor
  • Receptors, Cytokine / metabolism*
  • Receptors, Growth Factor / metabolism
  • Receptors, Interleukin / metabolism
  • Receptors, Interleukin-6
  • Receptors, OSM-LIF
  • Receptors, Oncostatin M
  • Tyrosine / metabolism

Substances

  • Antigens, CD
  • Ciliary Neurotrophic Factor
  • Cytokines
  • Growth Inhibitors
  • Interleukin-6
  • Leukemia Inhibitory Factor
  • Lymphokines
  • Membrane Glycoproteins
  • Nerve Tissue Proteins
  • Peptides
  • Proteins
  • Proto-Oncogene Proteins
  • Receptor, Ciliary Neurotrophic Factor
  • Receptors, Cytokine
  • Receptors, Growth Factor
  • Receptors, Interleukin
  • Receptors, Interleukin-6
  • Receptors, OSM-LIF
  • Receptors, Oncostatin M
  • Oncostatin M
  • Cytokine Receptor gp130
  • Tyrosine
  • Protein-Tyrosine Kinases
  • Janus Kinase 1
  • Janus Kinase 2