Flavonone and chalcone derivatives from Cryptocarya kurzii

J Nat Prod. 1993 Jul;56(7):1153-63. doi: 10.1021/np50097a021.

Abstract

Four complex flavanones, kurziflavolactones A [2], B [3], C [4], and D [5] and a complex chalcone 6 with an unprecedented carbon side chain on the flavanone or chalcone A ring have been isolated from a Malaysian plant, Cryptocarya kurzii (Lauraceae). Their structures were determined by extensive spectroscopic analysis, especially 2D nmr experiments. Compounds 3 and 6 showed slight cytotoxicity against KB cells, with IC50 values of 4 and 15 micrograms/ml, respectively. A biosynthetic pathway for the formation of these compounds is suggested.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Chalcone / chemistry
  • Chalcone / isolation & purification*
  • Chalcone / pharmacology
  • Drug Screening Assays, Antitumor
  • Flavonoids / chemistry
  • Flavonoids / isolation & purification*
  • Flavonoids / pharmacology
  • Humans
  • KB Cells
  • Magnetic Resonance Spectroscopy
  • Malaysia
  • Plants, Medicinal / chemistry*

Substances

  • Antineoplastic Agents, Phytogenic
  • Flavonoids
  • kurziflavolactone A
  • kurziflavolactone C
  • Chalcone