Abstract
A 67-year-old man had mucosal ulcerations and bullous and lichenoid skin lesions resembling those of several other patients with underlying neoplasms. Computed tomography revealed an occult retroperitoneal sarcoma. Autoantibodies pathogenic to epithelia induce this syndrome, which has been termed "paraneoplastic pemphigus." Imaging for an occult neoplasm should be considered in patients with similar mucosal and skin lesions.
Publication types
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Case Reports
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Aged
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Autoantibodies / blood
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Biopsy
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Combined Modality Therapy
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Cyclophosphamide / administration & dosage
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Cyclophosphamide / therapeutic use
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Cytoskeletal Proteins / immunology
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Desmoplakins
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Humans
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Immunoglobulins, Intravenous / therapeutic use
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Lymphoma, Non-Hodgkin / complications*
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Lymphoma, Non-Hodgkin / diagnosis
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Lymphoma, Non-Hodgkin / surgery
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Male
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Paraneoplastic Syndromes / diagnosis
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Paraneoplastic Syndromes / drug therapy
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Paraneoplastic Syndromes / etiology*
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Pemphigus / drug therapy
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Pemphigus / etiology*
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Plasmapheresis
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Prednisone / administration & dosage
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Prednisone / therapeutic use
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Radiotherapy
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Retroperitoneal Neoplasms / complications*
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Retroperitoneal Neoplasms / diagnosis
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Retroperitoneal Neoplasms / surgery
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Tomography, X-Ray Computed
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Ultrasonography
Substances
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Autoantibodies
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Cytoskeletal Proteins
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Desmoplakins
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Immunoglobulins, Intravenous
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Cyclophosphamide
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Prednisone