Rocuronium bromide in the ICU: dose finding and pharmacokinetics

Eur J Anaesthesiol Suppl. 1995 Sep:11:79-80.


Thirty patients requiring elective ventilation in the ICU received either intermittent boluses (25 patients) or a continuous infusion (five patients) of rocuronium. Degree of block was monitored by train-of-four stimuli and maintained at one twitch either observed or palpated. All patients were sedated with intermittent doses or an infusion of 0.14-0.4 microgram kg-1 h-1 of midazolam and received a continuous infusion of either sufentanil or fentanyl (0.25-2.0 micrograms kg-1 h-1). Control of ventilation was better with the continuous infusion of rocuronium, but these patients also had a more intense block receiving 9.9 +/- 1.3 micrograms kg-1 min-1 as compared to 6.4 +/- 2.3 micrograms kg-1 min-1 in the bolus group. Elimination half-time, volume of distribution at steady-state, and mean residence time were significantly greater than in surgical patients receiving comparable infusions, but plasma clearance was similar.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Androstanols* / administration & dosage
  • Androstanols* / pharmacokinetics
  • Androstanols* / pharmacology
  • Anesthesia*
  • Half-Life
  • Humans
  • Infusions, Intravenous
  • Injections, Intravenous
  • Intensive Care Units
  • Middle Aged
  • Neuromuscular Nondepolarizing Agents* / administration & dosage
  • Neuromuscular Nondepolarizing Agents* / pharmacokinetics
  • Neuromuscular Nondepolarizing Agents* / pharmacology
  • Rocuronium


  • Androstanols
  • Neuromuscular Nondepolarizing Agents
  • Rocuronium