The Caenorhabditis elegans sel-1 gene, a negative regulator of lin-12 and glp-1, encodes a predicted extracellular protein

Genetics. 1996 May;143(1):237-47. doi: 10.1093/genetics/143.1.237.


The Caenorhabditis elegans lin-12 and glp-1 genes encode members of the LIN-12/NOTCH family of receptors. The sel-1 gene was identified as an extragenic suppressor of a lin-12 hypomorphic mutant. We show in this report that the sel-1 null phenotype is wild type, except for an apparent elevation in lin-12 and glp-1 activity in sensitized genetic backgrounds, and that this genetic interaction seems to be lin-12 and glp-1 specific. We also find that sel-1 encodes a predicted extracellular protein, with a domain sharing sequence similarity to predicted proteins from humans and yeast. SEL-1 may interact with the LIN-12 and GLP-1 receptors and/or their respective ligands to down-regulate signaling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Caenorhabditis elegans / genetics*
  • Caenorhabditis elegans / physiology
  • Caenorhabditis elegans Proteins*
  • Cloning, Molecular
  • DNA Primers
  • Gene Expression Regulation
  • Genes, Helminth*
  • Genes, Regulator*
  • Genotype
  • Helminth Proteins / biosynthesis*
  • Helminth Proteins / genetics*
  • Membrane Glycoproteins / biosynthesis*
  • Membrane Glycoproteins / genetics
  • Membrane Proteins / biosynthesis*
  • Membrane Proteins / genetics*
  • Models, Genetic
  • Molecular Sequence Data
  • Mutagenesis
  • Operon
  • Polymerase Chain Reaction
  • Receptors, Notch
  • Restriction Mapping


  • Caenorhabditis elegans Proteins
  • DNA Primers
  • Glp-1 protein, C elegans
  • Helminth Proteins
  • Lin-12 protein, C elegans
  • Membrane Glycoproteins
  • Membrane Proteins
  • Receptors, Notch
  • SEL-1 protein, C elegans

Associated data

  • GENBANK/U50828
  • GENBANK/U50829