Glycosaminoglycans in urine and extracorporeal shock wave lithotripsy

Urol Res. 1995;23(6):401-5. doi: 10.1007/BF00698743.


In 50 calcium oxalate stone-forming patients, the total excretion of glycosaminoglycans (GAGs) and of four subgroups [chondroitin-4-sulfate (CS-A), chondroitin-6-sulfate (CS-C), dermatan sulfate (DS) and hyaluronic acid (HY)] were investigated before extracorporeal shock wave lithotripsy (ESWL) and during the subsequent 5 days. The standard value was determined by reference to a group of healthy test subjects. The excretion of GAGs was significantly higher in healthy test persons than in stone-forming patients. Twenty-four hours after ESWL administration, GAG excretion was enhanced significantly but returned to normal values over the course of 3 days. ESWL had no influence on the proportional composition of GAG subgroups CS-A, CS-C, DS and HY. The increase in GAG excretion after ESWL indicates a transient injury of renal tissue or of the mucus layer lining the urothelium. This lesion, however, can be regarded as temporary with later restitutio ad integrum.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Calcium Oxalate / metabolism
  • Chondroitin / metabolism
  • Chondroitin Sulfates / metabolism
  • Creatinine / urine
  • Dermatan Sulfate / metabolism
  • Epithelium / injuries
  • Epithelium / metabolism
  • Female
  • Glycosaminoglycans / urine*
  • Humans
  • Hyaluronic Acid / metabolism
  • Kidney / cytology
  • Kidney / injuries
  • Kidney / metabolism
  • Kidney Calculi / metabolism
  • Kidney Calculi / therapy
  • Lithotripsy*
  • Male
  • Metabolic Clearance Rate
  • Middle Aged
  • Predictive Value of Tests
  • Sex Factors


  • Glycosaminoglycans
  • Dermatan Sulfate
  • Calcium Oxalate
  • Hyaluronic Acid
  • Chondroitin
  • Chondroitin Sulfates
  • Creatinine