Saponins as vaccine adjuvants

Crit Rev Ther Drug Carrier Syst. 1996;13(1-2):1-55.

Abstract

Naturally occurring triterpene glycosides (saponins) from Quillaja saponaria have considerable adjuvant activity. Adjuvant functions include stimulation of high levels of antibody to T-dependent and T-independent antigens, induction of mouse IgG1, IgG2b, and IgG2a isotypes, and induction of cytotoxic T lymphocyte responses. This article reviews responses due to specific saponins of saponin preparations, effect of formulation, structure/function studies, and use in different preclinical and clinical vaccine applications.

Publication types

  • Review

MeSH terms

  • Adjuvants, Immunologic*
  • Animals
  • Antibody Formation
  • Antigen-Antibody Reactions
  • CD8-Positive T-Lymphocytes / cytology
  • CD8-Positive T-Lymphocytes / drug effects*
  • CD8-Positive T-Lymphocytes / immunology
  • Clinical Trials as Topic
  • Drug Administration Routes
  • Drug Carriers / classification
  • Drug Carriers / metabolism
  • Feasibility Studies
  • Immunoglobulin G / immunology
  • Saponins / administration & dosage
  • Saponins / analysis
  • Saponins / immunology*
  • Saponins / isolation & purification
  • Saponins / metabolism
  • Saponins / pharmacology
  • Species Specificity
  • Structure-Activity Relationship
  • Vaccines*

Substances

  • Adjuvants, Immunologic
  • Drug Carriers
  • Immunoglobulin G
  • Saponins
  • Vaccines