Comparison of iodixanol and ioxaglate for adult aortography and renal/visceral angiography: a phase III clinical trial

Acad Radiol. 1996 Sep:3 Suppl 3:S507-13. doi: 10.1016/s1076-6332(05)80367-8.


Rationale and objectives: We investigated whether iodixanol offers improved safety or tolerance compared with ioxaglate and evaluated whether iodixanol-enhanced radiographs are diagnostically comparable or superior to those produced with ioxaglate. Iodixanol is a new isosmotic hexa-iodinated nonionic contrast agent being evaluated for intravascular use.

Methods: Fifty-four adult patients undergoing renal or visceral angiography, aortography, or both were enrolled in a prospective, randomized, double-blind, two-center study in which iodixanol and ioxaglate were compared. Subjects were monitored for adverse events, injection-associated discomfort, and changes in laboratory parameters and vital signs. Efficacy was measured by the overall quality of angiographic enhancement.

Results: No serious adverse events occurred during this trial. Mild-to-moderate adverse events were more common in patients receiving ioxaglate (p = .041). Injection-associated pain was reported by three patients receiving ioxaglate and none receiving iodixanol (p = .093). Clinical laboratory and vital-sign data showed no differences between groups, and there was no difference in the overall quality of angiographic visualization (p = .711).

Conclusion: Iodixanol resulted in improved safety and patient tolerability while providing images of equivalent diagnostic efficacy compared with ioxaglate.

Publication types

  • Clinical Trial
  • Clinical Trial, Phase III
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Angiography*
  • Aortography*
  • Contrast Media* / adverse effects
  • Double-Blind Method
  • Female
  • Humans
  • Ioxaglic Acid* / adverse effects
  • Kidney / blood supply*
  • Male
  • Middle Aged
  • Prospective Studies
  • Triiodobenzoic Acids* / adverse effects
  • Viscera / blood supply*


  • Contrast Media
  • Triiodobenzoic Acids
  • iodixanol
  • Ioxaglic Acid