Meleda disease: report of two cases investigated by electron microscopy

Dermatology. 1996;193(4):358-61. doi: 10.1159/000246295.


We report 2 cases of clinically typical Meleda disease in a family from Herzegovina. Electron microscopy did not reveal major ultrastructural anomalies of keratinization; however, the transition from stratum granulosum to stratum corneum appeared to occur less abruptly than normally by a stepwise process suggesting a slowing down of terminal cornification.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Biopsy
  • Diagnosis, Differential
  • Family
  • Female
  • Humans
  • Keratoderma, Palmoplantar / diagnosis
  • Keratoderma, Palmoplantar / genetics
  • Keratoderma, Palmoplantar / pathology*
  • Male
  • Microscopy, Electron