Microsatellite polymorphism of the alpha 1-antichymotrypsin gene locus associated with sporadic Alzheimer's disease

Hum Genet. 1997 Jan;99(1):27-31. doi: 10.1007/s004390050304.

Abstract

A variant of the apolipoprotein E gene, APOE*4, is associated with both sporadic Alzheimer's disease (AD) and a subset of familial AD and this association is stronger with early as opposed to late onset AD. Both APOE*4 and alpha 1-antichymotrypsin (ACT) will accelerate the rate of amyloid filament formation and are major constituents of the plaques associated with AD. We now show that a dinucleotide microsatellite allele in the 5'-flanking sequence of the ACT gene, designated A10, in association with APOE*4 significantly increases the risk of developing sporadic AD, which accounts for the majority of AD cases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / epidemiology
  • Alzheimer Disease / genetics*
  • Alzheimer Disease / pathology
  • Apolipoprotein E4
  • Apolipoproteins E / genetics
  • Brain / metabolism
  • Brain / pathology
  • Dinucleotide Repeats
  • Humans
  • Microsatellite Repeats*
  • Middle Aged
  • Molecular Sequence Data
  • Odds Ratio
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*
  • Reference Values
  • Risk Assessment
  • alpha 1-Antichymotrypsin / genetics*

Substances

  • Apolipoprotein E4
  • Apolipoproteins E
  • alpha 1-Antichymotrypsin

Associated data

  • GENBANK/X94997