Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors

J P Sheridan; S A Marsters; R M Pitti; A Gurney; M Skubatch; D Baldwin; L Ramakrishnan; C L Gray; K Baker; W I Wood; A D Goddard; P Godowski; A Ashkenazi

doi:10.1126/science.277.5327.818

Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors

Science. 1997 Aug 8;277(5327):818-21. doi: 10.1126/science.277.5327.818.

Authors

J P Sheridan¹, S A Marsters, R M Pitti, A Gurney, M Skubatch, D Baldwin, L Ramakrishnan, C L Gray, K Baker, W I Wood, A D Goddard, P Godowski, A Ashkenazi

Affiliation

¹ Department of Molecular Oncology, Genentech, South San Francisco, CA 94080-4918, USA.

PMID: 9242611
DOI: 10.1126/science.277.5327.818

Abstract

TRAIL (also called Apo2L) belongs to the tumor necrosis factor family, activates rapid apoptosis in tumor cells, and binds to the death-signaling receptor DR4. Two additional TRAIL receptors were identified. The receptor designated death receptor 5 (DR5) contained a cytoplasmic death domain and induced apoptosis much like DR4. The receptor designated decoy receptor 1 (DcR1) displayed properties of a glycophospholipid-anchored cell surface protein. DcR1 acted as a decoy receptor that inhibited TRAIL signaling. Thus, a cell surface mechanism exists for the regulation of cellular responsiveness to pro-apoptotic stimuli.

MeSH terms

Amino Acid Sequence
Apoptosis Regulatory Proteins
Apoptosis*
Cell Membrane / metabolism
Cells, Cultured
GPI-Linked Proteins
Glycosylphosphatidylinositols / metabolism
HeLa Cells
Humans
Ligands
Membrane Glycoproteins / metabolism*
Molecular Sequence Data
NF-kappa B / metabolism
Receptors, TNF-Related Apoptosis-Inducing Ligand
Receptors, Tumor Necrosis Factor / chemistry
Receptors, Tumor Necrosis Factor / genetics
Receptors, Tumor Necrosis Factor / metabolism*
Receptors, Tumor Necrosis Factor, Member 10c
Signal Transduction
TNF-Related Apoptosis-Inducing Ligand
Transfection
Tumor Cells, Cultured
Tumor Necrosis Factor Decoy Receptors
Tumor Necrosis Factor-alpha / metabolism*

Substances

Apoptosis Regulatory Proteins
GPI-Linked Proteins
Glycosylphosphatidylinositols
Ligands
Membrane Glycoproteins
NF-kappa B
Receptors, TNF-Related Apoptosis-Inducing Ligand
Receptors, Tumor Necrosis Factor
Receptors, Tumor Necrosis Factor, Member 10c
TNF-Related Apoptosis-Inducing Ligand
TNFRSF10A protein, human
TNFRSF10B protein, human
TNFRSF10C protein, human
TNFSF10 protein, human
Tumor Necrosis Factor Decoy Receptors
Tumor Necrosis Factor-alpha

Associated data

GENBANK/AF012535
GENBANK/AF012536