Pneumonic tularemia in a patient with chronic granulomatous disease

Clin Infect Dis. 1997 Sep;25(3):630-3. doi: 10.1086/513777.

Abstract

We report the case of a 14-year-old boy with granulomatous pneumonia caused by Francisella tularensis. In addition, an autosomal recessive form of chronic granulomatous disease was diagnosed. Both F. tularensis and chronic granulomatous disease are associated with pulmonary granulomas. To our knowledge, this is the first report of F. tularensis infection in a patient with chronic granulomatous disease. The relationship between these two processes is discussed.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Anti-Bacterial Agents
  • Drug Therapy, Combination / therapeutic use
  • Francisella tularensis / immunology
  • Genes, Recessive
  • Granulomatous Disease, Chronic / complications*
  • Granulomatous Disease, Chronic / genetics
  • Granulomatous Disease, Chronic / immunology
  • Humans
  • Male
  • NADPH Oxidases
  • Neutrophils / immunology
  • Neutrophils / physiology
  • Phosphoproteins / deficiency
  • Phosphoproteins / genetics
  • Pneumonia, Bacterial / complications*
  • Pneumonia, Bacterial / drug therapy
  • Pneumonia, Bacterial / immunology
  • Tularemia / complications*
  • Tularemia / drug therapy
  • Tularemia / immunology

Substances

  • Anti-Bacterial Agents
  • Phosphoproteins
  • NADPH Oxidases
  • neutrophil cytosolic factor 1