Evaluation of the gastroprotective effect of Laurus nobilis seeds on ethanol induced gastric ulcer in rats

J Ethnopharmacol. 1997 Sep;58(1):9-14. doi: 10.1016/s0378-8741(97)00070-6.

Abstract

The possible antiulcerogenic activity of Laurus nobilis seeds was tested on experimentally (ethanol) induced gastric ulcer in rats. The results indicated antiulcerogenic activity for 20 and 40% aqueous extracts as well as for the oily fraction of these seeds. In acute toxicity studies, the aqueous extract was found safe with LD50 compared to oil LD50 0.33 ml/kg body weight.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Animals
  • Anti-Ulcer Agents / therapeutic use*
  • Disease Models, Animal
  • Ethanol / administration & dosage
  • Female
  • Lethal Dose 50
  • Male
  • Mice
  • Oils / chemistry
  • Plant Extracts / therapeutic use*
  • Plant Extracts / toxicity
  • Rats
  • Seeds
  • Stomach Ulcer / chemically induced
  • Stomach Ulcer / drug therapy*

Substances

  • Anti-Ulcer Agents
  • Oils
  • Plant Extracts
  • Ethanol