A comparison of zopiclone and propiomazine as hypnotics in outpatients: a multicentre, double-blind, randomized, parallel-group comparison of zopiclone and propiomazine in insomniacs

Curr Med Res Opin. 1997;13(10):565-72. doi: 10.1185/03007999709113330.

Abstract

In a double-blind, parallel-group study of 135 patients with a mean age of 60 years, zopiclone 5 mg was compared with propiomazine 25 mg. The patients rated their sleep in a diary. There were statistically significant differences in favour of zopiclone for nine out of 13 variables measuring subjective sleep quality and quantity. Concerning side-effects, bad taste was reported more frequently in the zopiclone group and restless legs in the propiomazine group.

Publication types

  • Clinical Trial
  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antipsychotic Agents / therapeutic use*
  • Azabicyclo Compounds
  • Double-Blind Method
  • Female
  • Humans
  • Hypnotics and Sedatives / therapeutic use*
  • Male
  • Middle Aged
  • Phenothiazines / therapeutic use*
  • Piperazines / therapeutic use*
  • Restless Legs Syndrome / chemically induced
  • Sleep Initiation and Maintenance Disorders / drug therapy*
  • Taste / drug effects

Substances

  • Antipsychotic Agents
  • Azabicyclo Compounds
  • Hypnotics and Sedatives
  • Phenothiazines
  • Piperazines
  • zopiclone
  • propiomazine