Peptide recognition by PTB and PDZ domains

Curr Opin Struct Biol. 1997 Dec;7(6):835-8. doi: 10.1016/s0959-440x(97)80155-8.


Protein tyrosine binding (PTB) and 'post synaptic density disc-large zo-1' (PDZ) domains bind to short peptidic ligands by augmentation of one of the domain's beta sheets and other recognition mechanisms. The two domain classes have a superficial resemblance to each other, even though no sequential homology exists. The structural bases of the interactions are well understood for the few domains now experimentally determined, and ligand-target pairs can probably be identified in favorable cases by analogy with the known domains. For both PTB and PDZ classes, functional activities are still not fully defined: it is possible that these domain classes, along with pleckstrin homology domains, have multiple roles.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Ligands
  • Models, Molecular
  • Peptide Fragments / chemistry
  • Peptide Fragments / metabolism
  • Phosphotyrosine / metabolism*
  • Protein Binding
  • Protein Structure, Secondary
  • Proteins / chemistry*
  • Proteins / metabolism
  • src Homology Domains


  • Ligands
  • Peptide Fragments
  • Proteins
  • Phosphotyrosine