Trials of bright light exposure and melatonin administration in a patient with non-24 hour sleep-wake syndrome

Psychiatry Clin Neurosci. 1998 Apr;52(2):261-2. doi: 10.1111/j.1440-1819.1998.tb01064.x.


We report a patient with non-24 h sleep-wake syndrome (non-24) whose free-running sleep-wake cycle was successfully treated with both scheduled bright light exposure and melatonin treatment. In the present study, morning bright light as well as evening melatonin phase-advanced sleep-wake cycles and melatonin rhythm. Both these procedures achieved appropriate entrainment to a 24 h day. However, the patient did not continue morning bright light therapy after the discharge. Rising at appropriate times in the morning for bright light therapy was difficult for him to continue. Melatonin treatment was better tolerated because of its ease of application.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Circadian Rhythm / drug effects*
  • Combined Modality Therapy
  • Humans
  • Male
  • Melatonin / administration & dosage*
  • Phototherapy*
  • Sleep Stages / drug effects*
  • Sleep Wake Disorders / therapy*
  • Treatment Outcome
  • Wakefulness / drug effects*


  • Melatonin