Novel thiazolidinedione derivatives with retinoid synergistic activity

Biol Pharm Bull. 1998 May;21(5):547-9. doi: 10.1248/bpb.21.547.


Several arylmethylidene thiazolidinediones were synthesized and their retinoidal activities were examined. TZ181 (7a), having a benzanilide skeleton, exhibited differentiation-inducing activity in HL-60 cell assay, while TZ191 (7b), the N-methylated analog of TZ181 (7a), TZ245 (9) and TZ335 (10) acted as retinoid synergists like the RXR-selective ligand, LGD1069 (5).

MeSH terms

  • Cell Differentiation / drug effects
  • Drug Synergism
  • HL-60 Cells
  • Humans
  • Retinoids / pharmacology*
  • Structure-Activity Relationship
  • Thiazoles / pharmacology*


  • Retinoids
  • Thiazoles